GLI1 and ZIC1

Number of citations of the paper that reports this interaction (PubMedID 11238441)
57

Data Source:
HPRD (in vivo, in vitro)

		GLI1	ZIC1
Description		GLI family zinc finger 1	Zic family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Central Nervous System Development Brain Development Adult Walking Behavior Regulation Of Smoothened Signaling Pathway Spinal Cord Development Cell Differentiation Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS			Chin dimples ( 27182965) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793)
Interacting Genes		18 interacting genes: CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT5 RAI1 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2	3 interacting genes: GLI1 GLI2 GLI3
Entrez ID		2735	7545
HPRD ID		01311	02718
Ensembl ID		ENSG00000111087	ENSG00000152977
Uniprot IDs		B4DNF7 P08151	Q15915
PDB IDs		2GLI 4BLB 4KMD 5OM0
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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