PCBD2 and BRF1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PCBD2	BRF1
Description		pterin-4 alpha-carbinolamine dehydratase 2	BRF1 RNA polymerase III transcription initiation factor subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding Transcription Factor Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process	DNA-templated Transcription, Initiation Transcription By RNA Polymerase III Transcription Initiation From RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Positive Regulation Of Transcription By RNA Polymerase III RNA Polymerase III Preinitiation Complex Assembly
Pathways			RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)	Huntington's disease progression ( 28642124) Mean platelet volume ( 22139419 27863252) Platelet count ( 29403010 27863252) Platelet distribution width ( 27863252)
Interacting Genes		33 interacting genes: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A F2RL1 FBXO7 GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC
Entrez ID		84105	2972
HPRD ID		17824	05361
Ensembl ID		ENSG00000132570	ENSG00000185024
Uniprot IDs		Q9H0N5	A0A024R6P8 Q92994 V9HVY2
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?
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