PCBD2 and MED30

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PCBD2	MED30
Description		pterin-4 alpha-carbinolamine dehydratase 2	mediator complex subunit 30
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process	Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Transcription, DNA-templated
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)	Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Dimensional psychopathology (Arousal) ( 29496196) Facial attractiveness (female raters) ( 30946739) Fasting blood glucose ( 29212154) Kawasaki disease ( 22446961) Leprosy ( 27976721) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Urate levels in obese individuals ( 25811787) Vestibular neuritis ( 30079052)
Interacting Genes		33 interacting genes: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A F2RL1 FBXO7 GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	13 interacting genes: APP DOCK8 KRTAP10-9 MED17 MED22 MED27 MED28 MED4 MED8 MED9 MTA2 PCBD2 SS18L1
Entrez ID		84105	90390
HPRD ID		17824	11631
Ensembl ID		ENSG00000132570	ENSG00000164758
Uniprot IDs		Q9H0N5	Q96HR3
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?
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