GRWD1 and RPL23

Number of citations of the paper that reports this interaction (PubMedID 29991511)
1

Data Source:
BioGRID (pull down)

		GRWD1	RPL23
Description		glutamate rich WD repeat containing 1	ribosomal protein L23
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Protein-containing Complex	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Extracellular Exosome
	Molecular Function	Chromatin Binding DNA Replication Origin Binding RNA Binding Protein Binding Histone Binding	Transcription Coactivator Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Ubiquitin Protein Ligase Binding Large Ribosomal Subunit RRNA Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Ribosomal Protein Import Into Nucleus SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Viral Transcription Protein-DNA Complex Disassembly Protein Stabilization Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Cellular Response To Actinomycin D Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Anisomycin Puromycin
Diseases
GWAS			Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		2 interacting genes: ESR1 RPL23	10 interacting genes: APP BCCIP CDC42 CLU DAPP1 EPS8L2 GRWD1 IPO5 PTEN RELA
Entrez ID		83743	9349
HPRD ID		11013	04716
Ensembl ID		ENSG00000105447	ENSG00000125691
Uniprot IDs		Q9BQ67	A0A024R1Q8 P62829
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6QZP
Enriched GO Terms of Interacting Partners?
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