CDC7 and DIAPH1

Number of citations of the paper that reports this interaction (PubMedID 12065429)
28

Data Source:
HPRD (in vitro)

		CDC7	DIAPH1
Description		cell division cycle 7	diaphanous related formin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Secretory Granule Membrane Ruffle Membrane Mitotic Spindle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Rho GTPase Binding Ion Channel Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Microtubule-based Process Protein Localization To Microtubule Neutrophil Degranulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine Regulation Of Cell Motility
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6	RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Mean platelet volume ( 27863252)
Interacting Genes		26 interacting genes: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1	16 interacting genes: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		8317	1729
HPRD ID		10345	03670
Ensembl ID		ENSG00000097046	ENSG00000131504
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	A0A2R8Y5N1 O60610 Q6URC4
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR
Enriched GO Terms of Interacting Partners?
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