CDC7 and DBF4

Number of citations of the paper that reports this interaction (PubMedID 10523313)
68

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		CDC7	DBF4
Description		cell division cycle 7	DBF4 zinc finger
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1	18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		8317	10926
HPRD ID		10345	10371
Ensembl ID		ENSG00000097046	ENSG00000006634
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	B4DXK0 B7Z8C6 Q9UBU7
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR	4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?
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