ESS2 and CDK5RAP3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ESS2	CDK5RAP3
Description		ess-2 splicing factor homolog	CDK5 regulatory subunit associated protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nervous System Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Brain Development Cell Proliferation Regulation Of Phosphatase Activity Viral Process Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		11 interacting genes: CDK5RAP3 CRP DHX16 FRA10AC1 LYST PFDN1 RACK1 RBM4 TTC14 VIM WNK2	12 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4
Entrez ID		8220	80279
HPRD ID		03452	12190
Ensembl ID		ENSG00000100056	ENSG00000108465
Uniprot IDs		F8WEF8 Q96DF8	Q96JB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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