ESS2 and CRP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ESS2	CRP
Description		ess-2 splicing factor homolog	C-reactive protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Extracellular Region Extracellular Space
	Molecular Function	Molecular_function Protein Binding	Complement Component C1q Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nervous System Development	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium Negative Regulation Of Blood Vessel Diameter Regulation Of Interleukin-8 Secretion
Pathways			Classical antibody-mediated complement activation
Drugs			N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases			Systemic lupus erythematosus
GWAS			Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 24763700 29403010 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Interacting Genes		11 interacting genes: CDK5RAP3 CRP DHX16 FRA10AC1 LYST PFDN1 RACK1 RBM4 TTC14 VIM WNK2	21 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70
Entrez ID		8220	1401
HPRD ID		03452	00422
Ensembl ID		ENSG00000100056	ENSG00000132693
Uniprot IDs		F8WEF8 Q96DF8	P02741
PDB IDs			1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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