CDK5RAP3 and TSPYL4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CDK5RAP3	TSPYL4
Description		CDK5 regulatory subunit associated protein 3	TSPY like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding	Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Brain Development Cell Proliferation Regulation Of Phosphatase Activity Viral Process Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Nucleosome Assembly
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)	Fast beta electroencephalogram ( 28040410) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4	8 interacting genes: CCDC85B CDK5RAP3 CELSR3 NAP1L3 NINL PNMA1 TFIP11 TRIM38
Entrez ID		80279	23270
HPRD ID		12190	18236
Ensembl ID		ENSG00000108465	ENSG00000187189
Uniprot IDs		Q96JB5	Q9UJ04
PDB IDs
Enriched GO Terms of Interacting Partners?
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