AKT3 and TCL1A

Number of citations of the paper that reports this interaction (PubMedID 11707444)
27

Data Source:
HPRD (in vitro, in vivo)

		AKT3	TCL1A
Description		AKT serine/threonine kinase 3	T cell leukemia/lymphoma 1A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Mitochondrial Genome Maintenance Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Cellular Senescence	Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Antisaccade task score ( 31596458) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Height ( 28552196) Menarche (age at onset) ( 23599027) Non-glioblastoma glioma ( 28346443) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Self-reported risk-taking behaviour ( 30181555)	Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		11 interacting genes: FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2	23 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CEP55 DNMT3A FLACC1 GOLGA2 H2AW LNX2 LSM3 NTAQ1 PRTFDC1 TCF4 TP53BP2 TRAF1 TTC33 TXLNA TXLNB WDR47
Entrez ID		10000	8115
HPRD ID		06441	01744
Ensembl ID		ENSG00000117020	ENSG00000100721
Uniprot IDs		A0A5F9ZHU3 Q9Y243	A0A024R6G5 P56279
PDB IDs		2X18	1JSG
Enriched GO Terms of Interacting Partners?
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