FXR1 and FBXO4

Number of citations of the paper that reports this interaction (PubMedID 29142209)
9

Data Source:
BioGRID (enzymatic study)

		FXR1	FBXO4
Description		FMR1 autosomal homolog 1	F-box protein 4
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Axon Growth Cone Ribonucleoprotein Granule Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Costamere Dendritic Spine Dendritic Spine Neck Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse Dendritic Filopodium	Ubiquitin Ligase Complex Cell Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Apoptotic Process Muscle Organ Development Negative Regulation Of Translation Cell Differentiation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Positive Regulation Of Gene Silencing By MiRNA Positive Regulation Of Response To DNA Damage Stimulus	Protein Polyubiquitination Aging Posttranscriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Post-translational Protein Modification Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint
Pathways		Signaling by BRAF and RAF fusions	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Metabolite levels ( 23823483) Schizophrenia ( 25056061 19571811 29483656 30285260)
Interacting Genes		13 interacting genes: CEP126 CRMP1 CSNK2A1 CYFIP2 ERG28 FBXO4 FMR1 FXR2 GBP2 HSPB1 LRIF1 LUC7L2 PRSS23	7 interacting genes: CCND1 CDC34 ELF4 FXR1 SKP1 TERF1 UBE2D2
Entrez ID		8087	26272
HPRD ID		02892	09949
Ensembl ID		ENSG00000114416	ENSG00000151876
Uniprot IDs		A0A0F7KYT8 A0A0F7L1S3 P51114	B3KNA0 D6RAJ6 Q9UKT5
PDB IDs		2CPQ 3KUF 3O8V	3L2O 3L82
Enriched GO Terms of Interacting Partners?
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