COL18A1 and HNRNPD

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		COL18A1	HNRNPD
Description		collagen type XVIII alpha 1 chain	heterogeneous nuclear ribonucleoprotein D
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Synapse Ribonucleoprotein Complex
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	AT DNA Binding Chromatin Binding RNA Binding Protein Binding Transcription Factor Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Animal Organ Morphogenesis Extracellular Matrix Organization Positive Regulation Of Cell Migration Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process	MRNA Splicing, Via Spliceosome Liver Development Regulation Of Transcription, DNA-templated RNA Processing RNA Catabolic Process RNA Metabolic Process Cerebellum Development Regulation Of Telomere Maintenance Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Regulation Of RNA Metabolic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity Hepatocyte Dedifferentiation
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs			Artenimol
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankle injury ( 28957384) Blood protein levels ( 30072576 29875488) Bone mineral density (total hip) ( 29883787) Early-onset Parkinson's disease ( 28256260) Hippocampal atrophy ( 22745009) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)	Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		8 interacting genes: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2	88 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BCL2 BET1L BRCA1 C1QBP CAPN1 CD81 CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FLNA GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPF HNRNPH3 HNRNPK HSPA4 HSPB1 HSPB2 IGF2BP2 IL7R IMMP2L IMMT ING4 LDHA LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 NTMT1 P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SNRPC SREK1 SUMO4 SYNCRIP TNPO1 TRN-GTT2-7 TSEN34 UBE2I UQCRC1 VEGFA VHL YBX1
Entrez ID		80781	3184
HPRD ID		00382	03206
Ensembl ID		ENSG00000182871	ENSG00000138668
Uniprot IDs		D3DSM4 D3DSM5 P39060	A0A024RDB4 A0A024RDF4 A1LU37 Q14103
PDB IDs		1BNL 3HON 3HSH	1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0
Enriched GO Terms of Interacting Partners?
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