COL18A1 and GPC4

Number of citations of the paper that reports this interaction (PubMedID 11336704)
58

Data Source:
HPRD (in vitro)

		COL18A1	GPC4
Description		collagen type XVIII alpha 1 chain	glypican 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Animal Organ Morphogenesis Extracellular Matrix Organization Positive Regulation Of Cell Migration Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Signal Transduction Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankle injury ( 28957384) Blood protein levels ( 30072576 29875488) Bone mineral density (total hip) ( 29883787) Early-onset Parkinson's disease ( 28256260) Hippocampal atrophy ( 22745009) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)
Interacting Genes		8 interacting genes: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2	9 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PTEN PTPRD PTPRF
Entrez ID		80781	2239
HPRD ID		00382	02160
Ensembl ID		ENSG00000182871	ENSG00000076716
Uniprot IDs		D3DSM4 D3DSM5 P39060	O75487
PDB IDs		1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?
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