COL18A1 and FBLN2

Number of citations of the paper that reports this interaction (PubMedID 10544250)
18

Data Source:
HPRD (in vitro)

		COL18A1	FBLN2
Description		collagen type XVIII alpha 1 chain	fibulin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Animal Organ Morphogenesis Extracellular Matrix Organization Positive Regulation Of Cell Migration Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankle injury ( 28957384) Blood protein levels ( 30072576 29875488) Bone mineral density (total hip) ( 29883787) Early-onset Parkinson's disease ( 28256260) Hippocampal atrophy ( 22745009) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		8 interacting genes: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2	23 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 MRPS25 NID1 PRELP VCAN ZNF408
Entrez ID		80781	2199
HPRD ID		00382	00630
Ensembl ID		ENSG00000182871	ENSG00000163520
Uniprot IDs		D3DSM4 D3DSM5 P39060	P98095 Q86V58 Q9Y3V7
PDB IDs		1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?
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