WDR61 and MCPH1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
3

Data Source:
BioGRID (two hybrid)

		WDR61	MCPH1
Description		WD repeat domain 61	microcephalin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex	Cell Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance
Pathways		Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Condensation of Prophase Chromosomes
Drugs
Diseases			Primary microcephaly (MCPH)
GWAS		Eyebrow thickness ( 26926045)	Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		10 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ	68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2
Entrez ID		80349	79648
HPRD ID		15236	06174
Ensembl ID		ENSG00000140395	ENSG00000147316
Uniprot IDs		H0YL19 Q9GZS3	Q8NEM0
PDB IDs		3OW8 6GMH	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
Enriched GO Terms of Interacting Partners?
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