WDR61 and ACVR1

Number of citations of the paper that reports this interaction (PubMedID 15761153)
246

Data Source:
HPRD (in vivo)

		WDR61	ACVR1
Description		WD repeat domain 61	activin A receptor type 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Protein Tyrosine Kinase Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation	G1/S Transition Of Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Heart Development Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cardiac Muscle Cell Fate Commitment BMP Signaling Pathway Involved In Heart Development Endocardial Cushion Cell Fate Commitment Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs			ATP 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases			Fibrodysplasia ossificans progressiva (FOP)
GWAS		Eyebrow thickness ( 26926045)	Severe gingival inflammation ( 28459102)
Interacting Genes		10 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ	70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TDGF1 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		80349	90
HPRD ID		15236	00021
Ensembl ID		ENSG00000140395	ENSG00000115170
Uniprot IDs		H0YL19 Q9GZS3	D3DPA4 Q04771
PDB IDs		3OW8 6GMH	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6SRH 6SZM 6T6D 6T8N
Enriched GO Terms of Interacting Partners?
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