GKAP1 and TLE1

		GKAP1	TLE1
Description		G kinase anchoring protein 1	TLE family member 1, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding
	Biological Process	Signal Transduction Positive Regulation Of Insulin Receptor Signaling Pathway	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Chronotype ( 30696823) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252)	Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		14 interacting genes: AP3B1 DHFR FXR2 HDDC3 HGS HSD11B1 MFAP1 NDN PRKG1 SH3BP4 SOX18 TLE1 UBQLN1 UBQLN4	88 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 DNAH5 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GKAP1 GOLM1 GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 KIF27 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64
Entrez ID		80318	7088
HPRD ID		17042	02557
Ensembl ID		ENSG00000165113	ENSG00000196781
Uniprot IDs		Q5VSY0	B4DEF9 Q04724 Q59EF7
PDB IDs			1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?