TLE1 and KDM6A

Number of citations of the paper that reports this interaction (PubMedID 9854018)
21

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		TLE1	KDM6A
Description		TLE family member 1, transcriptional corepressor	lysine demethylase 6A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Beta-catenin-TCF Complex	Nuclear Chromatin Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis	In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Respiratory System Process Chromatin Remodeling Positive Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Multicellular Organism Growth Mesodermal Cell Differentiation Notochord Morphogenesis Histone H3-K4 Methylation Oxidation-reduction Process Canonical Wnt Signaling Pathway Histone H3-K27 Demethylation Cardiovascular System Development
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		88 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 DNAH5 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GKAP1 GOLM1 GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 KIF27 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64	9 interacting genes: H3-4 H3C1 H3C14 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1
Entrez ID		7088	7403
HPRD ID		02557	02131
Ensembl ID		ENSG00000196781	ENSG00000147050
Uniprot IDs		B4DEF9 Q04724 Q59EF7	B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 O15550 Q59HG3 Q86TD1
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ	3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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