GKAP1 and HSD11B1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GKAP1	HSD11B1
Description		G kinase anchoring protein 1	hydroxysteroid 11-beta dehydrogenase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding	11-beta-hydroxysteroid Dehydrogenase [NAD(P)] Activity Steroid Binding 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Signal Transduction Positive Regulation Of Insulin Receptor Signaling Pathway	Glucocorticoid Biosynthetic Process Steroid Catabolic Process Lung Development Oxidation-reduction Process
Pathways			Glucocorticoid biosynthesis
Drugs			NADH Prednisone Carbenoxolone 2'-Monophosphoadenosine 5'-Diphosphoribose 2-(N-Morpholino)-Ethanesulfonic Acid Corticosterone INCB13739 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide enyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide (5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one
Diseases			Cortisone reductase deficiency (CRD)
GWAS		Chronotype ( 30696823) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252)	Alopecia areata ( 25608926)
Interacting Genes		14 interacting genes: AP3B1 DHFR FXR2 HDDC3 HGS HSD11B1 MFAP1 NDN PRKG1 SH3BP4 SOX18 TLE1 UBQLN1 UBQLN4	3 interacting genes: CD36 CENPF GKAP1
Entrez ID		80318	3290
HPRD ID		17042	07042
Ensembl ID		ENSG00000165113	ENSG00000117594
Uniprot IDs		Q5VSY0	P28845 X5D2L1
PDB IDs			1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4C7J 4C7K 4HFR 4HX5 4IJU 4IJV 4IJW 4K1L 4P38 4YYZ 5PGU 5PGV 5PGW 5PGX 5PGY 5QII
Enriched GO Terms of Interacting Partners?
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