CEP63 and SYT17

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CEP63	SYT17
Description		centrosomal protein 63	synaptotagmin 17
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GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Trans-Golgi Network Plasma Membrane Exocytic Vesicle
	Molecular Function	Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Clathrin Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Alcohol dependence ( 21876473) Parkinson's disease ( 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		42 interacting genes: ALOX5 ARFIP2 ARNT2 CAMKK2 CCNI CDK1 CEP57L1 DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 HGS INTS6L KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNX4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TSHZ3 TXLNA USHBP1 ZCCHC10	17 interacting genes: APP APTX CCDC85B CEP63 CEP70 CHMP4A FAM9B GMCL1 IKZF1 MEOX1 MEOX2 NIF3L1 NINL RUNDC3A SSX2IP TRAF2 TSC22D4
Entrez ID		80254	51760
HPRD ID		07826	17425
Ensembl ID		ENSG00000182923	ENSG00000103528
Uniprot IDs		Q96MT8	H3BN78 H3BRH9 Q9BSW7
PDB IDs		6CSU 6CSV	2ENP
Enriched GO Terms of Interacting Partners?
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