CEP63 and DTNB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CEP63	DTNB
Description		centrosomal protein 63	dystrobrevin beta
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Height ( 18391951) Heschl's gyrus morphology ( 25130324) Intracranial aneurysm ( 29531279) LDL cholesterol ( 21347282) Macular thickness ( 30535121) Multiple myeloma ( 22120009 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Resistant hypertension ( 31545351) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 28552196) Working memory ( 31598132)
Interacting Genes		42 interacting genes: ALOX5 ARFIP2 ARNT2 CAMKK2 CCNI CDK1 CEP57L1 DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 HGS INTS6L KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNX4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TSHZ3 TXLNA USHBP1 ZCCHC10	30 interacting genes: ABI2 ABI3 BEGAIN CCDC85B CEP55 CEP63 DMD DTNBP1 GGA1 HMG20A KIF5A KIF5B KRT31 KRT40 MTUS2 NDEL1 NUP62 PPFIA1 PPFIBP2 PRTFDC1 SNTG1 SNTG2 SPZ1 TRAF2 TSACC TXLNA USHBP1 UTRN VCP ZBTB9
Entrez ID		80254	1838
HPRD ID		07826	09091
Ensembl ID		ENSG00000182923	ENSG00000138101
Uniprot IDs		Q96MT8	B7Z202 B7Z6A9 E7EVB6 E9PEY4 O60941 Q1I0L3
PDB IDs		6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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