STN1 and TPP1

Number of citations of the paper that reports this interaction (PubMedID 25172512)
7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		STN1	TPP1
Description		STN1 subunit of CST complex	tripeptidyl peptidase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton CST Complex	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation IRE1-mediated Unfolded Protein Response Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region
Pathways		Telomere C-strand synthesis initiation	XBP1(S) activates chaperone genes
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Chronic obstructive pulmonary disease ( 30804561) Uterine fibroids ( 30194396)
Interacting Genes		8 interacting genes: APP GOLGA2 LRRK2 MFHAS1 MVP TPP1 TUBGCP4 ZDHHC17	6 interacting genes: CTC1 NMB POT1 STN1 TERT TINF2
Entrez ID		79991	1200
HPRD ID		14872	06415
Ensembl ID		ENSG00000107960	ENSG00000166340
Uniprot IDs		Q9H668	O14773
PDB IDs		4JOI 4JQF	1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?
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