TPP1 and CTC1

Number of citations of the paper that reports this interaction (PubMedID 25172512)
7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TPP1	CTC1
Description		tripeptidyl peptidase 1	CST telomere replication complex component 1
Image
GO Annotations	Cellular Component	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome	Nuclear Chromosome, Telomeric Region Nucleus CST Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding	Single-stranded DNA Binding Protein Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation IRE1-mediated Unfolded Protein Response Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region	Telomere Maintenance Cellular Response To DNA Damage Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Bone Marrow Development Hematopoietic Stem Cell Proliferation Replicative Senescence
Pathways		XBP1(S) activates chaperone genes	Telomere C-strand synthesis initiation
Drugs
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Bipolar disorder ( 28115744) Telomere length ( 23001564)
Interacting Genes		6 interacting genes: CTC1 NMB POT1 STN1 TERT TINF2	2 interacting genes: APPBP2 TPP1
Entrez ID		1200	80169
HPRD ID		06415	07980
Ensembl ID		ENSG00000166340	ENSG00000178971
Uniprot IDs		O14773	Q2NKJ3
PDB IDs		1R60 3EDY 3EE6	5W2L
Enriched GO Terms of Interacting Partners?
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