TPP1 and STN1

Number of citations of the paper that reports this interaction (PubMedID 25172512)
7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TPP1	STN1
Description		tripeptidyl peptidase 1	STN1 subunit of CST complex
Image
GO Annotations	Cellular Component	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton CST Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding	Single-stranded DNA Binding Protein Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation IRE1-mediated Unfolded Protein Response Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication
Pathways		XBP1(S) activates chaperone genes	Telomere C-strand synthesis initiation
Drugs
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Chronic obstructive pulmonary disease ( 30804561) Uterine fibroids ( 30194396)
Interacting Genes		6 interacting genes: CTC1 NMB POT1 STN1 TERT TINF2	8 interacting genes: APP GOLGA2 LRRK2 MFHAS1 MVP TPP1 TUBGCP4 ZDHHC17
Entrez ID		1200	79991
HPRD ID		06415	14872
Ensembl ID		ENSG00000166340	ENSG00000107960
Uniprot IDs		O14773	Q9H668
PDB IDs		1R60 3EDY 3EE6	4JOI 4JQF
Enriched GO Terms of Interacting Partners?
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