ABCC2 and SLC9A3R1

Number of citations of the paper that reports this interaction (PubMedID 12615054)
22

Data Source:
HPRD (in vitro)

		ABCC2	SLC9A3R1
Description		ATP binding cassette subfamily C member 2	SLC9A3 regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus	Ruffle Cell Nucleus Cytoplasm Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Tip Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Self-association Protein-containing Complex Binding Myosin II Binding Protein N-terminus Binding Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding
	Biological Process	Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Xenobiotic Catabolic Process Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Benzylpenicillin Metabolic Process Drug Transmembrane Export Drug Transport Across Blood-brain Barrier	Renal Sodium Ion Transport Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Glutathione Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Excretion Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Golgi Localization Negative Regulation Of Protein Kinase B Signaling Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome
Drugs		ATP Sulfinpyrazone
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)	Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748)	Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Fibrinogen ( 20031577) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1	64 interacting genes: ABCC2 ABCC4 ADRB2 AKAP10 AKT1 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 CABP1 CD300A CFTR CLCN3 CNGA2 COG1 CTNNB1 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PHLPP1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468
Entrez ID		1244	9368
HPRD ID		03065	05406
Ensembl ID		ENSG00000023839	ENSG00000109062
Uniprot IDs		Q92887	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H
Enriched GO Terms of Interacting Partners?
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