ZXDC and WDR5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		ZXDC	WDR5
Description		ZXD family zinc finger C	WD repeat domain 5
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Nucleic Acid Binding DNA-binding Transcription Factor Activity Protein Binding LRR Domain Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding	Protein Binding Methylated Histone Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Positive Regulation Of Transcription, DNA-templated	Skeletal System Development Neuron Projection Development Post-translational Protein Modification Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Gluconeogenesis Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation
Pathways			PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Pursuit maintenance gain ( 29064472)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Intraocular pressure ( 30591961)
Interacting Genes		13 interacting genes: APP ATXN1 CIITA JTB MTDH NR1H2 NR1H3 POGZ RORA SH3GL2 SMN1 TK1 WDR5	24 interacting genes: APP ATN1 BHLHE41 CHD8 H1-2 H3-4 H3C1 H4-16 HSF2 IKBKG KANSL1 KANSL2 KMT2A MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SRPK2 SSX2IP TERF2IP TP53 ZXDC
Entrez ID		79364	11091
HPRD ID		14420	10614
Ensembl ID		ENSG00000070476	ENSG00000196363
Uniprot IDs		Q2QGD7	P61964
PDB IDs			2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR 5M23 5M25 5SXM 5VFC 6BYN 6D9X 6DAI 6DAK 6DAR 6DAS 6DY7 6DYA 6E1Y 6E1Z 6E22 6E23 6IAM 6KIU 6KIV 6KIW 6KIX 6KIZ
Enriched GO Terms of Interacting Partners?
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