WDR5 and ATN1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		WDR5	ATN1
Description		WD repeat domain 5	atrophin 1
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Methylated Histone Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Skeletal System Development Neuron Projection Development Post-translational Protein Modification Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Gluconeogenesis Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation	Negative Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Neuron Apoptotic Process
Pathways		PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation	Regulation of PTEN gene transcription
Drugs
Diseases			Dentatorubropallidoluysian atrophy (DRPLA)
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Intraocular pressure ( 30591961)
Interacting Genes		24 interacting genes: APP ATN1 BHLHE41 CHD8 H1-2 H3-4 H3C1 H4-16 HSF2 IKBKG KANSL1 KANSL2 KMT2A MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SRPK2 SSX2IP TERF2IP TP53 ZXDC	93 interacting genes: AGRN ALG13 ARF3 ATRX BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CTNND2 DMPK DVL1 DVL2 ECM1 EFEMP1 EFEMP2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HINFP HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP4-12 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 PCSK5 PDCD6IP PFKL PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SIAH1 SIAH2 SLIT1 SPAG5 SSPOP STXBP4 SYVN1 TEP1 TLE1 TLE5 TRIP6 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZSWIM8
Entrez ID		11091	1822
HPRD ID		10614	06311
Ensembl ID		ENSG00000196363	ENSG00000111676
Uniprot IDs		P61964	P54259 Q86V38
PDB IDs		2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR 5M23 5M25 5SXM 5VFC 6BYN 6D9X 6DAI 6DAK 6DAR 6DAS 6DY7 6DYA 6E1Y 6E1Z 6E22 6E23 6IAM 6KIU 6KIV 6KIW 6KIX 6KIZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?