ZXDC and CIITA

Number of citations of the paper that reports this interaction (PubMedID 16600381)
10

Data Source:
HPRD (two hybrid, in vivo)

		ZXDC	CIITA
Description		ZXD family zinc finger C	class II major histocompatibility complex transactivator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Nucleoplasm Cytosol PML Body
	Molecular Function	Nucleic Acid Binding DNA-binding Transcription Factor Activity Protein Binding LRR Domain Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding	DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Kinase Activity Transferase Activity, Transferring Acyl Groups Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Inflammatory Response Immune Response Phosphorylation Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling
Drugs
Diseases			Bare lymphocyte syndrome (BLS) type2 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Metabolite levels ( 23823483) Pursuit maintenance gain ( 29064472)	Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 20190752) Nasopharyngeal carcinoma ( 27436580) Systemic lupus erythematosus ( 27399966 26502338) Ulcerative colitis ( 20228799)
Interacting Genes		13 interacting genes: APP ATXN1 CIITA JTB MTDH NR1H2 NR1H3 POGZ RORA SH3GL2 SMN1 TK1 WDR5	17 interacting genes: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC
Entrez ID		79364	4261
HPRD ID		14420	02475
Ensembl ID		ENSG00000070476	ENSG00000179583
Uniprot IDs		Q2QGD7	A0A087X2I7 A0A0B4J1S1 P33076 Q66X48
PDB IDs
Enriched GO Terms of Interacting Partners?
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