GNPTAB and AEN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GNPTAB	AEN
Description		N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	apoptosis enhancing nuclease
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Calcium Ion Binding Protein Binding	Nucleic Acid Binding Exonuclease Activity Protein Binding
	Biological Process	Lysosome Organization N-glycan Processing To Lysosome Secretion Of Lysosomal Enzymes Carbohydrate Phosphorylation	DNA Catabolic Process, Exonucleolytic RNA Catabolic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Viral Genome Replication Defense Response To Virus
Pathways
Drugs
Diseases		Mucolipidosis II and III, including: Mucolipidosis II / I-cell disease; Mucolipidosis III A / Pseudo-Hurler polydystrophy; Mucolipidosis III C
GWAS		Blood protein levels ( 29875488 28240269) Bone mineral density (total hip) ( 29883787)	Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)
Interacting Genes		8 interacting genes: AEN APP DISC1 FAM90A1 MAPK1 PSMA1 STAMBPL1 ZNF250	34 interacting genes: CRTC3 EMD EXOSC8 GNPTAB HOMEZ IKZF1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF473
Entrez ID		79158	64782
HPRD ID		11350	08573
Ensembl ID		ENSG00000111670	ENSG00000181026
Uniprot IDs		Q3T906	Q8WTP8
PDB IDs		2N6D
Enriched GO Terms of Interacting Partners?
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