CHM and RAB32

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		CHM	RAB32
Description		CHM Rab escort protein	RAB32, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Mitochondrion Mitochondrial Outer Membrane Early Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Endomembrane System Membrane Phagocytic Vesicle Membrane Early Endosome Lumen Melanosome Membrane Melanosome Mitochondria-associated ER Membrane Phagocytic Vesicle
	Molecular Function	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	Protein Targeting To Membrane Small GTPase Mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Post-translational Protein Modification	Intracellular Protein Transport Mitochondrion Organization Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Rab Protein Signal Transduction Endosome To Melanosome Transport Protein Localization To Membrane Phagosome Maturation Melanosome Assembly
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)	Leprosy ( 27976721 25642632 22019778) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A	2 interacting genes: CHM PRKAR2A
Entrez ID		1121	10981
HPRD ID		02312	06700
Ensembl ID		ENSG00000188419	ENSG00000118508
Uniprot IDs		A8K545 B4DRL9 P24386	Q13637
PDB IDs			4CYM 4CZ2 5OEC 5OED 6FF8
Enriched GO Terms of Interacting Partners?
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