YY1 and RYBP

Number of citations of the paper that reports this interaction (PubMedID 10369680)
68

Data Source:
HPRD (in vitro, in vivo)

		YY1	RYBP
Description		YY1 transcription factor	RING1 and YY1 binding protein
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Matrix Ino80 Complex PcG Protein Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex
	Molecular Function	Four-way Junction DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding SMAD Binding Promoter-specific Chromatin Binding	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II RNA Localization Cellular Response To DNA Damage Stimulus Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Negative Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Negative Regulation Of Interferon-beta Production Cellular Response To UV Response To Prostaglandin F Positive Regulation Of Transcription By RNA Polymerase II Camera-type Eye Morphogenesis Chromosome Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Multicellular Organism Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		57 interacting genes: APP ATF2 ATF6 ATF7 AURKA BAP1 BCCIP BRCA1 CDKN2A CREB1 CRKL DNMT3L E2F2 E2F3 EED EP300 FKBP1A FKBP3 GRN GTF2I HCFC1 HDAC2 HDAC3 HOXA11 INO80 KAT2B MTA2 MYC NEDD4L NFKB1 NOTCH1 NPM1 NR1H2 PPIA PSMD9 RAF1 RUVBL1 RUVBL2 RYBP SAP30 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TWIST1 UHRF2 YAF2 ZNF232 ZRANB2	28 interacting genes: ABL1 CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 MAPK8IP2 MDM2 NMI NOS1AP RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A YY1 ZFP42
Entrez ID		7528	23429
HPRD ID		02482	09607
Ensembl ID		ENSG00000100811	ENSG00000163602
Uniprot IDs		P25490	Q8N488
PDB IDs		1UBD 1ZNM 4C5I	3IXS
Enriched GO Terms of Interacting Partners?
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