RYBP and E2F6

Number of citations of the paper that reports this interaction (PubMedID 11171983)
91

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RYBP	E2F6
Description		RING1 and YY1 binding protein	E2F transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Multicellular Organism Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 25673412 28448500)	Diisocyanate-induced asthma ( 25918132) Sudden cardiac arrest ( 21658281)
Interacting Genes		28 interacting genes: ABL1 CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 MAPK8IP2 MDM2 NMI NOS1AP RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A YY1 ZFP42	28 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		23429	1876
HPRD ID		09607	04251
Ensembl ID		ENSG00000163602	ENSG00000169016
Uniprot IDs		Q8N488	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs		3IXS
Enriched GO Terms of Interacting Partners?
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