XRCC4 and APLF

Number of citations of the paper that reports this interaction (PubMedID 17396150)
59

Data Source:
HPRD (in vitro)

		XRCC4	APLF
Description		X-ray repair cross complementing 4	aprataxin and PNKP like factor
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs		S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		19 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		7518	200558
HPRD ID		15951	09848
Ensembl ID		ENSG00000152422	ENSG00000169621
Uniprot IDs		A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763	Q8IW19
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO	2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF
Enriched GO Terms of Interacting Partners?
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