APLF and GMCL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		APLF	GMCL1
Description		aprataxin and PNKP like factor	germ cell-less 1, spermatogenesis associated
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break	Nucleus Nuclear Matrix
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Protein Binding Identical Protein Binding
	Biological Process	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis	Multicellular Organism Development Spermatogenesis Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Atrial fibrillation ( 28416818 30061737 29892015) Colorectal or endometrial cancer ( 26621817) Whole brain grey matter density ( 31530798)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	63 interacting genes: APLF APOL6 AXIN1 BYSL C5orf60 CCDC25 CFAP410 CHIC2 CIB3 CLK2 CUL3 ELOA EMD FKBP1B FOSL2 FOXR1 FRMD6 GAGE1 GAGE12B GAGE12I GAGE2E GAGE5 GLRX3 GMCL2 GOLGA2 GRAMD1A HYKK IL17F KAT5 KIFC3 KPNA2 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR NEBL NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PTPN7 QRICH1 RAD54B SHQ1 SLC15A3 SNX20 STK3 SUMO1 SUMO1P1 SYT17 TMPO TRIM13 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 ZNF250
Entrez ID		200558	64395
HPRD ID		09848	13587
Ensembl ID		ENSG00000169621	ENSG00000087338
Uniprot IDs		Q8IW19	Q53SE7 Q96IK5
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF
Enriched GO Terms of Interacting Partners?
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