XRCC1 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 11163244)
163

Data Source:
HPRD (two hybrid, in vitro)

		XRCC1	PNKP
Description		X-ray repair cross complementing 1	polynucleotide kinase 3'-phosphatase
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane
	Molecular Function	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Single Strand Break Repair Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Via Nonhomologous End Joining Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Response To Drug Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleoside Monophosphate Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Height ( 31562340) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		19 interacting genes: APEX1 APLF APTX BRCA1 BTRC CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I	17 interacting genes: APP GZMK IKZF1 KDM1A KRTAP4-12 LMNA MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		7515	11284
HPRD ID		01909	09284
Ensembl ID		ENSG00000073050	ENSG00000039650
Uniprot IDs		B2RCY5 P18887 Q59HH7	Q96T60
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y	2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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