XRCC1 and PSMD8

		XRCC1	PSMD8
Description		X-ray repair cross complementing 1	proteasome 26S subunit, non-ATPase 8
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GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Proteasome Accessory Complex
	Molecular Function	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	Protein Binding
	Biological Process	Single Strand Break Repair Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Via Nonhomologous End Joining Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Response To Drug Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK - noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 31562340) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		19 interacting genes: APEX1 APLF APTX BRCA1 BTRC CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I	15 interacting genes: CCDC92 ELF4 GLP1R MTNR1B PLSCR2 PSG11 PSG5 PVR RPS19 SMAD2 SMAD9 SNRPD2 UBC UCHL5 XRCC1
Entrez ID		7515	5714
HPRD ID		01909	10171
Ensembl ID		ENSG00000073050	ENSG00000099341
Uniprot IDs		B2RCY5 P18887 Q59HH7	P48556 V9HW09
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y	5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK
Enriched GO Terms of Interacting Partners?
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