PNKP and ZBTB14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PNKP	ZBTB14
Description		polynucleotide kinase 3'-phosphatase	zinc finger and BTB domain containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane	Nucleus Nucleoplasm Nucleolus Cytosol Aggresome
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Nucleoside Monophosphate Kinase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleoside Monophosphate Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Cardiac Septum Development Negative Regulation Of Transcription, DNA-templated Coronary Vasculature Development
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Cerebral amyloid deposition (PET imaging) ( 26252872)
Interacting Genes		17 interacting genes: APP GZMK IKZF1 KDM1A KRTAP4-12 LMNA MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	37 interacting genes: AP1M1 ATP5PO BAZ2B BYSL CBX8 CDK16 CDKL3 CEP19 EAF1 EIF1AD ENKD1 EPM2AIP1 FAM161A FAM90A1 GORASP2 INTS3 KAT5 MAD2L1BP MFAP1 MORF4L2 NAA10 PIN1 PNKP POLR2L PRMT1 RNPS1 RPL9 RPS7 SCNM1 SDCBP SNRPB2 SYT16 TCEANC TXN2 ZBTB21 ZCCHC10 ZMAT2
Entrez ID		11284	7541
HPRD ID		09284	03674
Ensembl ID		ENSG00000039650	ENSG00000198081
Uniprot IDs		Q96T60	B2R850 O43829
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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