WNT2B and RAD21

Number of citations of the paper that reports this interaction (PubMedID 22145905)
9

Data Source:
BioGRID (two hybrid)

		WNT2B	RAD21
Description		Wnt family member 2B	RAD21 cohesin complex component
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Chromosome, Centromeric Region Chromatin Nuclear Cohesin Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Meiotic Cohesin Complex
	Molecular Function	Frizzled Binding	Chromatin Binding Protein Binding
	Biological Process	Chondrocyte Differentiation Lens Development In Camera-type Eye Male Gonad Development Cellular Response To Starvation Wnt Signaling Pathway Forebrain Regionalization Neuron Differentiation Cell Fate Commitment Canonical Wnt Signaling Pathway Lung Induction Mesenchymal-epithelial Cell Signaling Iris Morphogenesis Cornea Development In Camera-type Eye Hematopoietic Stem Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Sister Chromatid Cohesion Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle Protein Localization To Chromatin
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diastolic blood pressure ( 29403010 30487518) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pancreatic cancer ( 29422604 26098869) Potassium levels ( 29403010) Pulse pressure ( 30487518) Stroke ( 29531354) Systolic blood pressure ( 29403010 30487518 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Menopause (age at onset) ( 29773799)
Interacting Genes		2 interacting genes: BRCA1 RAD21	28 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		7482	5885
HPRD ID		03574	05924
Ensembl ID		ENSG00000134245	ENSG00000164754
Uniprot IDs		Q5TEH8 Q93097	A0A024R9J0 O60216
PDB IDs			4PJU 4PJW 4PK7 6RRC 6RRK
Enriched GO Terms of Interacting Partners?
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