RAD21 and DISC1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		RAD21	DISC1
Description		RAD21 cohesin complex component	DISC1 scaffold protein
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nuclear Cohesin Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Meiotic Cohesin Complex	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Cell Junction Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Sister Chromatid Cohesion Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle Protein Localization To Chromatin	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Cell Proliferation In Forebrain Pyramidal Neuron Migration Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Waist circumference ( 28552196)
Interacting Genes		28 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	107 interacting genes: ACTG1 ACTN2 AGTPBP1 AKAP6 ARIH2 ATF4 ATF5 ATF7IP BICD1 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP126 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FBXW7 FEZ1 FRYL GNB1 GNPTAB GPRASP2 GSK3B HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIFAP3 MACF1 MAP1A MEMO1 MLLT10 MPPED1 MVP MYH7 MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI RTRAF SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNKS TRAF3IP1 TRIO TSPOAP1 TUBB TUBB2A UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		5885	27185
HPRD ID		05924	05553
Ensembl ID		ENSG00000164754	ENSG00000162946
Uniprot IDs		A0A024R9J0 O60216	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs		4PJU 4PJW 4PK7 6RRC 6RRK	5V4B
Enriched GO Terms of Interacting Partners?
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