RAD21 and SMC1A

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		RAD21	SMC1A
Description		RAD21 cohesin complex component	structural maintenance of chromosomes 1A
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nuclear Cohesin Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Meiotic Cohesin Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Chromatin Binding Protein Binding	Chromatin Binding RNA Binding Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Sister Chromatid Cohesion Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle Protein Localization To Chromatin	Mitotic Sister Chromatid Segregation DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Regulation Of Mitotic Spindle Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Menopause (age at onset) ( 29773799)	Bipolar disorder ( 31043756)
Interacting Genes		28 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	17 interacting genes: ATM BLM BRCA1 ESR1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3
Entrez ID		5885	8243
HPRD ID		05924	02077
Ensembl ID		ENSG00000164754	ENSG00000072501
Uniprot IDs		A0A024R9J0 O60216	A0A384MR33 G8JLG1 Q14683 Q68EN4
PDB IDs		4PJU 4PJW 4PK7 6RRC 6RRK
Enriched GO Terms of Interacting Partners?
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