VCAM1 and CTSG

Number of citations of the paper that reports this interaction (PubMedID 11520773)
114

Data Source:
HPRD (in vitro)

		VCAM1	CTSG
Description		vascular cell adhesion molecule 1	cathepsin G
Image
GO Annotations	Cellular Component	Podosome Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Filopodium Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Integrin Binding Primary Amine Oxidase Activity Cell Adhesion Molecule Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Amine Metabolic Process Cytokine-mediated Signaling Pathway Membrane To Membrane Docking B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of T Cell Proliferation Regulation Of Immune Response Leukocyte Tethering Or Rolling Oxidation-reduction Process Interferon-gamma-mediated Signaling Pathway Cell-cell Adhesion In Response To Extracellular Stimulus Cellular Response To Amyloid-beta	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Extracellular Matrix Disassembly Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs		Ethanol Carvedilol Succinobucol	Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Multiple sclerosis ( 31604244 24076602 21833088) SjÃ¶gren's syndrome ( 24097067)	Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		13 interacting genes: CCL17 CCL22 CTSG ELANE ETFA EXOSC2 EZR IL13 ITGAD ITGB1 ITGB7 MSN USP2	28 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		7412	1511
HPRD ID		01888	00289
Ensembl ID		ENSG00000162692	ENSG00000100448
Uniprot IDs		P19320	P08311
PDB IDs		1IJ9 1VCA 1VSC	1AU8 1CGH 1KYN 1T32
Enriched GO Terms of Interacting Partners?
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