NR1H2 and SMPD1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		NR1H2	SMPD1
Description		nuclear receptor subfamily 1 group H member 2	sphingomyelin phosphodiesterase 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Apolipoprotein A-I Receptor Binding Signaling Receptor Activity Retinoid X Receptor Binding ATPase Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Multicellular Organism Development Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Lipid Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Ceramide Biosynthetic Process
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	Glycosphingolipid metabolism
Drugs		(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfinic acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein	Amlodipine Chlorpromazine Desipramine
Diseases			Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS			Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		48 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		7376	6609
HPRD ID		02660	06353
Ensembl ID		ENSG00000131408	ENSG00000166311
Uniprot IDs		F1D8P7 P55055	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6S4N 6S4T 6S4U	5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?
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