SMPD1 and ANXA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SMPD1	ANXA4
Description		sphingomyelin phosphodiesterase 1	annexin A4
Image
GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Ceramide Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Signal Transduction Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Interleukin-8 Secretion
Pathways		Glycosphingolipid metabolism
Drugs		Amlodipine Chlorpromazine Desipramine	Copper
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Neurological blood protein biomarker levels ( 31320639)	Atrial fibrillation ( 28416818 30061737) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5
Entrez ID		6609	307
HPRD ID		06353	00112
Ensembl ID		ENSG00000166311	ENSG00000196975
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	P09525 Q6LES2 Q6P452
PDB IDs		5I81 5I85 5I8R 5JG8	2ZOC
Enriched GO Terms of Interacting Partners?
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