NR1H2 and ROBO2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		NR1H2	ROBO2
Description		nuclear receptor subfamily 1 group H member 2	roundabout guidance receptor 2
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Plasma Membrane Cell Surface Integral Component Of Membrane Axolemma Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Apolipoprotein A-I Receptor Binding Signaling Receptor Activity Retinoid X Receptor Binding ATPase Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Multicellular Organism Development Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Lipid Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis	Metanephros Development Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Spinal Cord Development Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5
Drugs		(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfinic acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases			Vesicoureteral reflux
GWAS			Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Chronotype ( 30696823) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Hand grip strength ( 29691431) Hip circumference ( 28552196) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Type 2 diabetes ( 30297969)
Interacting Genes		48 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC	16 interacting genes: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4
Entrez ID		7376	6092
HPRD ID		02660	11895
Ensembl ID		ENSG00000131408	ENSG00000185008
Uniprot IDs		F1D8P7 P55055	Q9HCK4
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6S4N 6S4T 6S4U	1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?
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