ROBO2 and BNIP3L

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ROBO2	BNIP3L
Description		roundabout guidance receptor 2	BCL2 interacting protein 3 like
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Axolemma Extracellular Exosome	Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Membrane Nuclear Speck Intrinsic Component Of Membrane
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Metanephros Development Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Spinal Cord Development Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis	Negative Regulation Of Mitochondrial Membrane Potential Viral Process Positive Regulation Of Macroautophagy Mitochondrial Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Defense Response To Virus Negative Regulation Of Cell Death Cellular Response To Hypoxia Mitochondrial Outer Membrane Permeabilization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways		Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases		Vesicoureteral reflux
GWAS		Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Chronotype ( 30696823) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Hand grip strength ( 29691431) Hip circumference ( 28552196) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Type 2 diabetes ( 30297969)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Red cell distribution width ( 27863252) Schizophrenia ( 28991256 30285260)
Interacting Genes		16 interacting genes: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4	26 interacting genes: ADIPOQ BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 DOK5 DUSP3 ECM1 EWSR1 FATE1 GBP2 GNB5 KLHL23 LDLRAD1 LMNA MAP1LC3A NGFR RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11
Entrez ID		6092	665
HPRD ID		11895	07288
Ensembl ID		ENSG00000185008	ENSG00000104765
Uniprot IDs		Q9HCK4	O60238 Q6IBV1
PDB IDs		1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?
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