UCHL1 and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		UCHL1	TRIM63
Description		ubiquitin C-terminal hydrolase L1	tripartite motif containing 63
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Cellular Response To Drug Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1
Pathways		UCH proteinases	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phenethyl Isothiocyanate
Diseases		Parkinson's disease (PD)
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		7345	84676
HPRD ID		01877	05843
Ensembl ID		ENSG00000154277	ENSG00000158022
Uniprot IDs		P09936 V9HW74	Q969Q1
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
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