UBE2V2 and RFFL

Number of citations of the paper that reports this interaction (PubMedID 23695783)
9

Data Source:
BioGRID (pull down)

		UBE2V2	RFFL
Description		ubiquitin conjugating enzyme E2 V2	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm UBC13-MMS2 Complex Extracellular Exosome	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Activity	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Height ( 31562340)	Acute post-radiotherapy pain in breast cancer ( 31196165) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		33 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LNX1 LRIF1 MALT1 MKRN3 MOB4 MUL1 OTUB1 RC3H1 RC3H2 RFFL RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM21 TRIM5 TRIM54 TRIM63 UBC UBE2N XIAP ZNRF1	21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		7336	117584
HPRD ID		04300	11489
Ensembl ID		ENSG00000169139	ENSG00000092871
Uniprot IDs		A0M8W4 Q15819	Q8WZ73
PDB IDs		1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT	1Y02
Enriched GO Terms of Interacting Partners?
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