UBE2E1 and PRKN

Number of citations of the paper that reports this interaction (PubMedID 21376232)
324

Data Source:
BioGRID (pull down, pull down)

		UBE2E1	PRKN
Description		ubiquitin conjugating enzyme E2 E1	parkin RBR E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Ubiquitin Ligase Complex Cell Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm Lewy Body Presynapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific G Protein-coupled Receptor Binding Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Negative Regulation Of Protein Phosphorylation Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Binding Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein K27-linked Ubiquitination Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Protein Stabilization Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Zinc Ion Homeostasis Negative Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Mitochondrion To Lysosome Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Primary Amine Oxidase Activity Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Exosomal Secretion Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Pink/Parkin Mediated Mitophagy Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)
Interacting Genes		110 interacting genes: ARIH2 ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA7 UBASH3B UBE2G1 UBE3A UBOX5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	113 interacting genes: ADRM1 AIMP2 ARRB1 ARRB2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCNB1 CCND1 CDC34 CDK5 CHPF COMMD1 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EPS15 FAF1 FBP1 FBXO7 FBXW7 GPR37 GRIN2B HDAC6 HEXD HSD17B10 IKBKG MEOX1 MEOX2 MFN1 MFN2 NDUFA4L2 NEK2 PAFAH1B2 PDCD2 PICK1 PKM PLK1 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 RHOT1 RHOT2 SEPTIN4 SEPTIN5 SIM2 SNCA SNCAIP STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z UCHL1 USP30 VDAC1 YWHAH ZNF746
Entrez ID		7324	5071
HPRD ID		04225	03967
Ensembl ID		ENSG00000170142	ENSG00000185345
Uniprot IDs		A0A024R2K3 B7Z306 P51965	O60260 X5DR79
PDB IDs		1XR9 3BZH 4JJQ 5LBN 6FGA	1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13
Enriched GO Terms of Interacting Partners?
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