UBE2E1 and TRIM33

Number of citations of the paper that reports this interaction (PubMedID 25172487)
22

Data Source:
BioGRID (pull down)

		UBE2E1	TRIM33
Description		ubiquitin conjugating enzyme E2 E1	tripartite motif containing 33
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Co-SMAD Binding R-SMAD Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)	Autism ( 24189344) Chronotype ( 30696823) Mean corpuscular hemoglobin ( 27863252)
Interacting Genes		110 interacting genes: ARIH2 ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA7 UBASH3B UBE2G1 UBE3A UBOX5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	10 interacting genes: CTNNB1 ERG H3C1 NLGN3 SMAD3 TRIM24 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		7324	51592
HPRD ID		04225	10423
Ensembl ID		ENSG00000170142	ENSG00000197323
Uniprot IDs		A0A024R2K3 B7Z306 P51965	B3KN30 Q9UPN9
PDB IDs		1XR9 3BZH 4JJQ 5LBN 6FGA	3U5M 3U5N 3U5O 3U5P 5MR8
Enriched GO Terms of Interacting Partners?
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