TWIST1 and CHD4

Number of citations of the paper that reports this interaction (PubMedID 20714342)
97

Data Source:
BioGRID (pull down)

		TWIST1	CHD4
Description		twist family bHLH transcription factor 1	chromodomain helicase DNA binding protein 4
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding E-box Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Histone Phosphorylation Negative Regulation Of Histone Acetylation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Cell Motility Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cellular Senescence Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Coronary artery disease ( 30104761) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Ischemic stroke ( 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 27841878 29403010 30487518 30578418) Stroke ( 29531354) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)	Heel bone mineral density ( 30598549) Myopia (pathological) ( 23049088)
Interacting Genes		24 interacting genes: BCL6 CHD4 EP300 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MYOD1 NEIL3 PTEN RBBP7 RELA STAT3 TCF3 TCF4 TP53 TRIM28 YY1 YY2 ZIC3 ZRANB1	19 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 RNF8 RORC SMARCA4 SUMO2 TRIM27 TWIST1 UBE2I XRN1
Entrez ID		7291	1108
HPRD ID		03374	04472
Ensembl ID		ENSG00000122691	ENSG00000111642
Uniprot IDs		Q15672	F5GWX5 Q14839
PDB IDs		2MJV	1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG
Enriched GO Terms of Interacting Partners?
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